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May 09, 2022

Methyl 3,3-dimethyl-2-(1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido)butanoate (MDMB-4en-PINACA) is a synthetic cannabinoid receptor agonist.

Similar to other synthetic cannabinoids, it is sold as a ‘legal’ replacement for cannabis and controlled synthetic cannabinoids.

Because of their high potency, synthetic cannabinoids can pose a high risk of severe poisoning, which in some cases can be fatal.

MDMB-4en-PINACA (also incorrectly known as 5-CL-ADB-A) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.

MDMB-4en-PINACA differs from 5F-MDMB-PINACA due to replacement of 5-fluoropentyl with a pent-4-ene moiety (4-en).Related: BUY JWH-018 POWDER ONLINE

It acts as a potent agonist of the CB1 receptor with an EC50 value of 2.47 nM

Low-THC (Δ9-tetrahydrocannabinol) cannabis adulterated with synthetic cannabinoid receptor agonists (SCRAs) emerged in early 2020.

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The most commonly seen adulterant was the highly potent MDMB-4en-PINACA.

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By April 2020, 9 drug checking services in 8 countries identified this adulteration.

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Effective monitoring and warning require international cooperation.

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How to identify the drug

Described as a white powder. It has also been described internationally as a yellow/brown powder.
Usually sprayed onto plant material and smoked. It can also be vaped, injected or consumed orally.

High Alert has received information about the presence of MDMB-4en-PINACA. This synthetic cannabinoid (or 'synnie') is an analogue of 5F-ADB which, along with AMB-FUBINACA, was responsible for the majority of synthetic cannabinoid

How to recognise symptoms of the drug

The health risks and long-term effects of MDMB-4en-PINACA have not haven’t been studied in any scientific context, and the lethal toxicity is unknown.

The effects of MDMB-4en-PINACA are described as similar to 5F-ADB with:

Sedation, drowsiness

Slowed reaction times

Confusion, loss of touch with reality

Hypnotic

Loss of consciousness

It’s also addictive, and people have described experiencing long withdrawal periods when they stop using.

How to reduce harm from the drug

No drug use is the safest drug use. Synthetic cannabinoids are illegal, addictive and dangerous.

There’s a risk that dosing can be different, even within the same batch, as the people making the mixture probably aren’t experts. This makes it easier for them to apply a dangerous dose when preparing leaf mixture, further increasing the likelihood of overdoses, and possibly death.

The toxic dose of MDMB-4en-PINACA is unknown, but it’s likely to be similar to that of 5F-ADB - which is less than the size of your fingernail.

More information about synthetic cannabinoids is available through the NZ Drug Foundation.

It's likely there will be more detections of this type of synthetic cannabinoid in the future.

If you have heard of any reports of this drug, please let us know through the Report unusual effects page, the alert ID is N20/0004. All submissions are anonymous.

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What to do in an emergency

If someone falls unconscious after smoking synthetic cannabinoids, they could die.

Ask loudly if they're ok. Shake them gently.

If they aren’t responsive, dial 111 and ask for an ambulance.

Check they’re breathing and place them in a stable side position. If they aren’t breathing, start chest compressions.

People can often be very out of it after using synthetic cannabinoids. They may collapse or “drop”, foam at the mouth or experience temporary paralysis. Place them in a stable side position if possible and continuously monitor breathing.

Always call an ambulance if someone:

is unconscious;

stops breathing;

has a seizure;

is extremely agitated for longer than 15 minutes;

has chest pain or breathing difficulties for longer than 5 minutes.

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